This project proposes a novel fabrication approach for microsphere lasers by integrating microfluidic with thermally drawn fiber technology. The fiber platform contains built-in microchannels that can generate and excite uniform, gain-doped microspheres. These microsphere lasers exhibit whispering gallery modes that enable sensitive detection of tiny changes in the outside environment. The system offers scalable production, biocompatibility, and potential applications in biosensing, bioimaging, and integrated photonic systems, establishing a foundation for fiber-based diagnostic technologies and biomedical research.